The diagnosis of single-lesion paucibacillary leprosy remains a challenge. Reviews by expert dermatopathologists and quantitative polymerase chain reaction (qPCR) results obtained from 66 single-plaque biopsy samples were compared. Histological findings were graded as high (HP). medium (MP) or low (LP) probability of leprosy or other dermatopathy (OD). https://www.parisnaturalfoodes.shop/product-category/lions-mane-tincture/